Title: Inhibition of the Slow Afterhyperpolarization Restores the Classical Spike-timing Dependent 2 Plasticity Rule Obeyed in Layer 2/3 Pyramidal Cells of the Prefrontal Cortex 3 Running Title: Inhibition of Sahp Restores Stdp Rule 4 5
نویسندگان
چکیده
1 Title: Inhibition of the slow afterhyperpolarization restores the classical spike-timing dependent 2 plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex 3 Running title: Inhibition of sAHP restores STDP rule 4 5 Aleksey V. Zaitsev and Roger Anwyl 6 Department of Physiology, Trinity College, Dublin 2, Ireland; I.M. Sechenov Institute of 7 Evolutionary Physiology and Biochemistry of RAS, St. Petersburg, Russia 8 9 Corresponding author: Roger Anwyl 10 Address: Department of Physiology, Trinity College, College Green, Dublin 2, Ireland 11 e-mail: [email protected] 12 13 14 15 16 17 Articles in PresS. J Neurophysiol (October 5, 2011). doi:10.1152/jn.00452.2011
منابع مشابه
Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex.
The induction of long-term potentiation (LTP) and long-term depression (LTD) of excitatory postsynaptic currents was investigated in proximal synapses of layer 2/3 pyramidal cells of the rat medial prefrontal cortex. The spike timing-dependent plasticity (STDP) induction protocol of negative timing, with postsynaptic leading presynaptic stimulation of action potentials (APs), induced LTD as exp...
متن کاملContribution of Dopamine D1/5 Receptor Modulation of Post-Spike/Burst Afterhyperpolarization to Enhance Neuronal Excitability of Layer V Pyramidal Neurons in Prepubertal Rat Prefrontal Cortex
Dopamine (DA) receptors in the prefrontal cortex (PFC) modulate both synaptic and intrinsic plasticity that may contribute to cognitive processing. However, the ionic basis underlying DA actions to enhance neuronal plasticity in PFC remains ill-defined. Using whole-cell patch-clamp recordings in layer V-VI pyramidal cells in prepubertal rat PFC, we showed that DA, via activation of D1/5, but no...
متن کاملInput specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells.
Layer 2/3 (L2/3) pyramidal cells receive excitatory afferent input both from neighbouring pyramidal cells and from cortical and subcortical regions. The efficacy of these excitatory synaptic inputs is modulated by spike timing-dependent plasticity (STDP). Here we report that synaptic connections between L2/3 pyramidal cell pairs are located proximal to the soma, at sites overlapping those of ex...
متن کاملChanges of the EPSP waveform regulate the temporal window for spike-timing-dependent plasticity.
Using spike-timing-dependent plasticity (STDP) protocols that consist of pairing an EPSP and a postsynaptic backpropagating action potential (BAP), we investigated the contribution of the changes in EPSP waveform induced by the slow Ca2+-dependent K+-mediated afterhyperpolarization (sAHP) in the regulation of long-term potentiation (LTP). The "temporal window" between Schaffer collateral EPSPs ...
متن کاملAdrenergic gating of Hebbian spike-timing-dependent plasticity in cortical interneurons.
In pyramidal cells, the induction of spike-dependent plasticity (STDP) follows a simple Hebbian rule in which the order of presynaptic and postsynaptic firing dictates the induction of LTP or LTD. In contrast, cortical fast spiking (FS) interneurons, which control the rate and timing of pyramidal cell firing, reportedly express timing-dependent LTD, but not timing-dependent LTP. Because a misma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011